Analysis of Royal Jelly Apis Cerana as Therapeutic Candidate in Cbavd Based on Bioinformatics Studies

Background: Apis cerana honey bee is a native to Asia that spreads from Afghanistan, China, and Japan Indonesia. The productivity of bees can produce as much 2-5 kg per colony in year. Royal jelly the queen's nourishment, it produced by larvae, adult bees, young worker male larvae. CBAVD contributes 1–2% 20–25% males with subfertility. Aim: objective this study was evaluate Jelly Cerana potential therapeutic candidate for using bioinformatics approach. Method: This research method consisted converting nucleotides into amino acids, analyzing three-dimensional structure Protein, Ramachandran Plot Analysis, Analysis Epitope Allergen Proteins, Proteins were antigens toxins. Results: results conducted on six protein structures had very good validity based plot, GQME value, QmeanDisCo value. In addition, also obtained proteins are epitope, antigenic, non-allergenic, non-toxic. Conclusion: findings be used basis therapy against CBAVD.